Kuching Brand Diuretic Herbal Tea

Agripearl Sdn Bhd (674686-W)

Malay version  Chemotherapy Treatment

Flight  Oedema

Drink a cup or two of


Herbal Tea


It will make a difference

Traditional Knowledge validated by Modern Science

Scientific and other details of Misai Kuching are documented in major Pharmacopoeia and other Monographs, including

Unlike modern pharmaceuticals, medicinal or functional plants contain numerous complex active phytochemicals (plant chemicals). Take a look at the list present in Misai Kuching.

Flavonoid compounds a) Sinensetin       b) Tetramethylscutellarein       c) Eupatorin d) Salvigenin    e) Cirsimaritin       f) Pilloin       g) Rhamnazin       h) Trimethylapigenin     i) Tetramethylluteolin.
Diterpene Compounds a) Orthosiphonone       b) Orthosiphonone B     c) Orthosiphol A d) Orthosiphol B       e) Orthosiphol F       f) Orthosiphol G       g) Orthosiphol H       h) Neoorthosiphols A     i) Orthosiphol B     j) Staminol A.
Benzochromenes a) Orthochromene A     b) Methylripariochromene A    
c) Acetovaillochromene
Essential oilsa) β-elemene   b) β-caryophyllene   c) α-humulene  
d) β-caryophyllene oxide   e) Can-2-one   f) Palmitic acid
Others a) Inosital   b) Caffeic acid   c) Rosmaric acid   d) β-sitosterol  etc.

Phytochemicals in bold letters have been identified to have beneficial effects. The British Pharmacopoeia and the European Pharmacopoeia have detailed analytical procedures for the testing of Java Tea(Misai Kuching) where Sinensetin is assumed as the marker i.e. the most important phytochemical.

Studies on the Applications of Misai Kuching


The diuretic effects and improved circulation contribute considerably to improving and maintaining health. Some western herbal detox and slimming products add Java Tea to their formulations because of this property.

Diuretic Effects


This is the most extensively studied function of Misai Kuching. A number of animal studies showed diuretic effects with the extracts of Misai Kuching.1.2.3. The phytochemicals Sinensetin and the Tetramethoxy-
flavones "relaxes"
the muscles of walls of the internal vessels thus facilitating easier flow of urine and even the small particles that become stones. Methylripariochromene A was found to effect increased urinary flow and the excretion of sodium ions.5. The diuretic effects also explains the traditional use of Misai Kuching not only for urinary tract problems but also for gout, kidney stones7. and high blood pressure.

Anti-hypertensive Effects


Modern diuretic medications are often prescribed to treat high blood pressure. The explanation is simple. Reduced water and sodium ions in the blood, lowers the pressure and makes it easier for the heart to pump. In animal studies, the phytochemical Methylripariochromene A was shown to suppress contractions in the thoracic aorta and decrease the contractile force, without significantly affecting the heart beat rate.8. Ten of the other phytochemicals in Misai Kuching tea also exhibited this property to a lesser degree.9.

Anti-diabetic Effects


Experiments using the whole extract of Misai Kuching on laboratory rats produced a significant decrease in blood glucose concentration compared with that in a control group. Comparative experiments with glibenclamide (the standard anti-diabetic drug) showed that similar results could be obtained but only with very high dosage of Misai Kuching.10.

Cholesterol-inhibiting Effects


Laboratory studies have shown that Misai Kuching inhibits 15–lipoxygenase, an enzyme thought to be involved in the development of artery blockage by LDL Cholesterol. The inhibitory activity of the whole extract was greater than could be expected from the combined effect of each of the individual flavonoids, which shows that the synergy of the natural whole product is more effective than isolated phytochemicals or synthesised substitutes.11. More recently, studies have shown that Trimethylapigenin, Eupatorin and Tetramethylluteolin were the most effective phytochemicals in Misai Kuching producing this effect..12.

Tumour-inhibiting Effects


Sinensetin and Tetramethylscutellarein have shown activity against some class of tumour cells, where sinensetin was shown to be more effective than tetramethylscutellarein.13. Orthosiphols A and B have been reported to inhibit tumour promoter 12-O-tetradecanoylphorbol–13–acetate (TPA) in experiments with laboratory mice.14. Extracts of Misai Kuching leaves have been reported to have activity against skin cancer cell lines in laboratory studies. 15.
Recently Sinensetin has received significant attention in cancer research as it is shown to be an effective chemosensitizer. Chemosensitizers are materials that enhance the therapeutic effects of chemotherapy drugs, particularly with MDR (multi drug resistant) cells.16.More

Antioxidant Effects


Free radicals (by-products) are produced when the body cells use oxygen. These free radicals cause damage and can lead to problems such as heart diseases, cancer, etc. Substances called antioxidants present in various foods act as "free radical scavengers" mopping up these free radicals. Some of the most potent antioxidants are flavanoid compounds. The numerous flavanoid compounds along with some of the other compounds present in Misai Kuching has qualified it to be one of the most effective antioxidant foodstuff.17. 18.

Contraindications(Adverse interaction with other drugs or herbs)

None known, none reported


None known, none reported

Recommended Usage


Drink Kuching Herbal tea in the morning and after dinner. You are also advised to practise the healthy habit of drinking adequate fluids.

Direct from farm!



Premium Misai Kuching Tea


Organic Certification issued by Department of Agticulture, Malaysia
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It must be emphasized that all of the above findings show that the effects are mild (with normal dosage) as compared to the effects of modern drugs and cannot be relied on as treatment. However unlike modern drugs, Misai Kuching has no known or reported side effects. Although the extracts of Misai Kuching are used in medicinal formulations by some European companies, Kuching Herbal Tea is promoted, only as functional food. It is especially recommended for people with a family history of the mentioned ailments.

So there you have it – the simple, safe, natural path to good health. Drink a cup or two of Kuching Herbal Tea daily. You will surely appreciate and enjoy it. However, we would like to advise you that not all Misai Kuching tea that is being marketed are the same. You will understand why in next page.




Note: Botanical names for Misai Kuching are Orthosiphon Stamineus, Orthosiphon Aristatus and Orthosiphon Spicatus. Other common names are Kumis Kucing and Java Tea.

  1. The therapeutic effect of Java Tea and Equisetum arvense in patients with uratic diathesis. Tiktinsky OL, Bablumyan YA. Urol Nefrol 1983; 48: 47-50.
  2. Elaboration d’extraits végétaux adsorbés, réalisation d’extraits secs d’Orthosiphon stamineus Benth. (Adsorbed plant extracts, use of extracts of dried leaves of Orthosiphon stamineus Benth)
    Casadebaig-Lafon J, Jacob M, Cassanas G, Marion C, Puech A. Pharm Acta Helv 1989; 64: 220-224.
  3. Diuretic action of aqueous Orthosiphon extract in rats.
    Englert J, Harnischfeger G. Planta Med 1992; 58: 237-238.
  4. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L., and Arctostaphylos uva-ursi (L.) Spreng. in rats.
    Beaux D et al. Phytother Res 1998; 12: 498-501.
  5. Pharmacological investigation of some lipophilic flavonoids from Orthosiphon aristatus.
    Schut GA, Zwaving JH. Fitoterapia 1993; 64: 99-102.
  6. Studies on the individual and combined diuretic effects of four Vietnamese traditional herbal remedies (Zea mays, Imperata cylindrica, Plantago major and Orthosiphon stamineus).
    Du Dat D et al. J Ethnopharmacol 1992; 36: 225-231.
  7. Effects of Folia orthosiphonis on urinary stone promoters and inhibitors.
    Nirdnoy M, Muangman V. J Med Assoc Thailand 1991; 74: 319-321.
  8. Anti-hypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant.
    Matsubara T et al.Biol Pharm Bull 1999; 22: 1083-1088.
  9. Indonesian medicinal plants. 1) Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae).
    Ohashi K et al. Chem Pharm Bull 2000; 48: 433-435.
  10. Hypoglycaemic activity of the aqueous extract of Orthosiphon stamineus.
    Mariam A et al. Fitoterapia 1996; 67: 465-468.
  11. Lipophilic flavonoids from Orthosiphon spicatus as inhibitors of 15-lipoxygenase.
    Lyckander IM, Malterud KE. Acta Pharm Nord 1992; 4: 159-166.
  12. Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase.
    Lyckander IM, Malterud KE. Prostaglandins Leukot Essent Fatty Acids 1996; 54: 239-246.
  13. Flavonoids from Orthosiphon spicatus. Malterud KE et al Planta Med 1989; 55: 569-570.
  14. Orthosiphol A and B, novel diterpenoid inhibitors of TPA (12-O-tetradecanoylphorbol-13-acetate)-induced inflammation, from Orthosiphon stamineus.
    Masuda T et al. Tetrahedron 1992; 48: 6787-6792.
  15. Fractions of Orthosiphon stamineus Benth. leaves with antitumour activity. Preliminary results.
    Estevez NA. Rev Cuba Farm 1980; 14: 21.
  16. Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3',4'-pentamethoxyflavone (Sinensetin).
    Choi CH, Sun KH, An CS, Yoo JC, Hahm KS, Lee IH, Sohng JK, Kim YC. Biochem Biophys Res Commun. 2002 Jul 26;295(4):832-40.
  17. Sinensetin, eupatorin, 3′-hydroxy-5, 6, 7, 4′-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia.
    Akowuah, G. A., Zhari, I., Norhayati, I., Sadikun, A., Khamsah, S. M. Food Chemistry
  18. A recent study has shown that the extract of Orthosiphon stamineus exhibited antioxidant and free radical scavenging activities. The same extract when given to rats was also shown to prevent liver damage.
    Yam MF et al Am J Chin Med. 2007;35(1):115-26.

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